Alternative promoters and renal cell-specific regulation of the mouse type IIa sodium-dependent phosphate cotransporter gene
H Yamamoto, Y Tani, K Kobayashi, Y Taketani… - … et Biophysica Acta (BBA …, 2005 - Elsevier
The type IIa sodium-dependent phosphate cotransporter (NPT2a) expressed in renal
proximal tubules represents an important determinant in maintaining inorganic phosphate
(Pi) homeostasis. In the present study, we identified two variant transcripts of the mouse
NPT2a gene, Npt2a-v1 and Npt2a-v2, characterized by the presence of alternative first
exons (either exon 1A or exon 1B). The chromosomal structure analysis revealed that the
Npt2a gene comprises of two promoters (promoters 1 and 2) and 14 exons, and spans …
proximal tubules represents an important determinant in maintaining inorganic phosphate
(Pi) homeostasis. In the present study, we identified two variant transcripts of the mouse
NPT2a gene, Npt2a-v1 and Npt2a-v2, characterized by the presence of alternative first
exons (either exon 1A or exon 1B). The chromosomal structure analysis revealed that the
Npt2a gene comprises of two promoters (promoters 1 and 2) and 14 exons, and spans …
