Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase
E Jaeckel, L Klein, N Martin-Orozco… - The Journal of …, 2003 - rupress.org
E Jaeckel, L Klein, N Martin-Orozco, H von Boehmer
The Journal of experimental medicine, 2003•rupress.orgExperiments in nonobese diabetic (NOD) mice that lacked expression of glutamic acid
decarboxylase (GAD) in β cells have suggested that GAD represents an autoantigen
essential for initiating and maintaining the diabetogenic immune response. Several attempts
of inducing GAD-specific recessive tolerance to support this hypothesis have failed. Here we
report on successful tolerance induction by expressing a modified form of GAD under control
of the invariant chain promoter resulting in efficient epitope display. In spite of specific …
decarboxylase (GAD) in β cells have suggested that GAD represents an autoantigen
essential for initiating and maintaining the diabetogenic immune response. Several attempts
of inducing GAD-specific recessive tolerance to support this hypothesis have failed. Here we
report on successful tolerance induction by expressing a modified form of GAD under control
of the invariant chain promoter resulting in efficient epitope display. In spite of specific …
Experiments in nonobese diabetic (NOD) mice that lacked expression of glutamic acid decarboxylase (GAD) in β cells have suggested that GAD represents an autoantigen essential for initiating and maintaining the diabetogenic immune response. Several attempts of inducing GAD-specific recessive tolerance to support this hypothesis have failed. Here we report on successful tolerance induction by expressing a modified form of GAD under control of the invariant chain promoter resulting in efficient epitope display. In spite of specific tolerance insulitis and diabetes occurred with normal kinetics indicating that GAD is not an essential autoantigen in the pathogenesis of diabetes.
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