Presentation by myoblasts of an epitope from endogenous acetylcholine receptor indicates a potential role in the spreading of the immune response
J Curnow, L Corlett, N Willcox, A Vincent - Journal of neuroimmunology, 2001 - Elsevier
It is generally considered that myoblasts are unable to prime naive T cell responses without
help from professional antigen-presenting cells (APC). However, their ability to present
endogenous antigens to previously primed T lymphocytes in the secondary phase of a T cell
response has not been well studied. We show here that primary human myoblasts, when
stimulated with IFNγ to express class II MHC, can present an endogenous epitope, probably
an acetylcholine receptor (AChR) peptide, to a CD4+ AChR-specific T helper lymphocyte …
help from professional antigen-presenting cells (APC). However, their ability to present
endogenous antigens to previously primed T lymphocytes in the secondary phase of a T cell
response has not been well studied. We show here that primary human myoblasts, when
stimulated with IFNγ to express class II MHC, can present an endogenous epitope, probably
an acetylcholine receptor (AChR) peptide, to a CD4+ AChR-specific T helper lymphocyte …