Natural antibodies and complement link innate and acquired immunity
AF Ochsenbein, RM Zinkernagel - Immunology today, 2000 - cell.com
AF Ochsenbein, RM Zinkernagel
Immunology today, 2000•cell.comNatural or spontaneous antibodies are an essential part of the first line of defense against
hematogenically spreading infections, including viruses. These antibodies target virus–
antibody complexes and complement to the spleen. This prevents infections from reaching
vital organs and enhances neutralizing antibody responses, particularly when the antibody
is bound to a highly repetitive antigen.
hematogenically spreading infections, including viruses. These antibodies target virus–
antibody complexes and complement to the spleen. This prevents infections from reaching
vital organs and enhances neutralizing antibody responses, particularly when the antibody
is bound to a highly repetitive antigen.
Abstract
Natural or spontaneous antibodies are an essential part of the first line of defense against hematogenically spreading infections, including viruses. These antibodies target virus–antibody complexes and complement to the spleen. This prevents infections from reaching vital organs and enhances neutralizing antibody responses, particularly when the antibody is bound to a highly repetitive antigen.
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