PU. 1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene
M Rehli, A Poltorak, L Schwarzfischer… - Journal of Biological …, 2000 - ASBMB
The protein product of the Toll-like receptor (TLR) 4 gene has been implicated in the signal
transduction events induced by lipopolysaccharide (LPS). In mice, destructive mutations
ofTlr4 impede the normal response to LPS and cause a high susceptibility to Gram-negative
infection. Expression of TLR4 mRNA in humans is restricted to a small number of cell types,
including LPS-responsive myeloid cells, B-cells, and endothelial cells. To investigate the
molecular basis for TLR4 expression in cells of myeloid origin, we cloned the human TLR4 …
transduction events induced by lipopolysaccharide (LPS). In mice, destructive mutations
ofTlr4 impede the normal response to LPS and cause a high susceptibility to Gram-negative
infection. Expression of TLR4 mRNA in humans is restricted to a small number of cell types,
including LPS-responsive myeloid cells, B-cells, and endothelial cells. To investigate the
molecular basis for TLR4 expression in cells of myeloid origin, we cloned the human TLR4 …
