The etiology of primary open angle glaucoma, a leading cause of age-related blindness,
remains poorly defined, although elevated intraocular pressure (IOP) contributes to the
disease progression. To better understand the mechanisms causing elevated IOP from
aqueous humor circulation, we pursued proteomic analyses of trabecular meshwork (TM)
from glaucoma and age-matched control donors. These analyses demonstrated that
Cochlin, a protein associated with deafness disorder DFNA9, is present in glaucomatous but …