[HTML][HTML] β-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation
Y Chen, HC Whetstone, A Youn, P Nadesan… - Journal of Biological …, 2007 - ASBMB
Endochondral ossification is recapitulated during bone morphogenetic protein (BMP)-
induced ectopic bone formation. Although BMP and β-catenin have been investigated in
bone development and in mesenchymal cells, how they interact in this process is not clear.
We implanted recombinant BMP-2 into the muscle of mice to investigate the effect of β-
catenin signaling on BMP-induced in vivo endochondral bone formation. BMP-2 induced
expression of several Wnt ligands and their receptors and also activated β-catenin-mediated …
induced ectopic bone formation. Although BMP and β-catenin have been investigated in
bone development and in mesenchymal cells, how they interact in this process is not clear.
We implanted recombinant BMP-2 into the muscle of mice to investigate the effect of β-
catenin signaling on BMP-induced in vivo endochondral bone formation. BMP-2 induced
expression of several Wnt ligands and their receptors and also activated β-catenin-mediated …