Interleukin-2 receptor signaling in regulatory T cell development and homeostasis
MA Burchill, J Yang, KB Vang, MA Farrar - Immunology letters, 2007 - Elsevier
Interleukin-2 (IL2) was initially identified from supernatants of activated lymphocytes over 30
years ago. In the ensuing 15 years, the cDNAs for both IL2 and the three chains of the
interleukin-2 receptor (IL2R) were cloned. Subsequently, many of the downstream
biochemical pathways activated by the IL2 receptor complex were identified and the
structure of IL2 bound to this tripartite receptor complex was solved. Thus, we now have a
very good understanding of how each chain contributes to high affinity IL2 binding and …
years ago. In the ensuing 15 years, the cDNAs for both IL2 and the three chains of the
interleukin-2 receptor (IL2R) were cloned. Subsequently, many of the downstream
biochemical pathways activated by the IL2 receptor complex were identified and the
structure of IL2 bound to this tripartite receptor complex was solved. Thus, we now have a
very good understanding of how each chain contributes to high affinity IL2 binding and …