[HTML][HTML] Niemann-pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasis
EE Millard, K Srivastava, LM Traub, JE Schaffer… - Journal of Biological …, 2000 - ASBMB
The Niemann-Pick type C1 (NPC1) protein is a key participant in intracellular trafficking of
low density lipoprotein cholesterol, but its role in regulation of sterol homeostasis is not well
understood. To characterize further the function of NPC1, we generated stable Chinese
hamster ovary (CHO) cell lines overexpressing the human NPC1 protein (CHO/NPC1).
NPC1 overexpression increases the rate of trafficking of low density lipoprotein cholesterol
to the endoplasmic reticulum and the rate of delivery of endosomal cholesterol to the plasma …
low density lipoprotein cholesterol, but its role in regulation of sterol homeostasis is not well
understood. To characterize further the function of NPC1, we generated stable Chinese
hamster ovary (CHO) cell lines overexpressing the human NPC1 protein (CHO/NPC1).
NPC1 overexpression increases the rate of trafficking of low density lipoprotein cholesterol
to the endoplasmic reticulum and the rate of delivery of endosomal cholesterol to the plasma …