[HTML][HTML] Functional Co-expression of the β1 and Type IIA α Subunits of Sodium Channels in a Mammalian Cell Line (∗)
LL Isom, T Scheuer, AB Brownstein… - Journal of Biological …, 1995 - ASBMB
Brain sodium channels are a complex of α (260 kDa), β1 (36 kDa), and β2 (33 kDa)
subunits. α subunits are functional as voltage-gated sodium channels by themselves. When
expressed in Xenopus oocytes, β1 subunits accelerate the time course of sodium channel
activation and inactivation by shifting them to a fast gating mode, but α subunits expressed
alone in mammalian cells activate and inactivate rapidly without co-expression of β1
subunits. In these experiments, we show that the Chinese hamster cell lines CHO and 1610 …
subunits. α subunits are functional as voltage-gated sodium channels by themselves. When
expressed in Xenopus oocytes, β1 subunits accelerate the time course of sodium channel
activation and inactivation by shifting them to a fast gating mode, but α subunits expressed
alone in mammalian cells activate and inactivate rapidly without co-expression of β1
subunits. In these experiments, we show that the Chinese hamster cell lines CHO and 1610 …