Usefulness of behavioral and electrophysiological studies in transgenic models of Alzheimer's disease
A Sant'Angelo, F Trinchese, O Arancio - Neurochemical research, 2003 - Springer
A Sant'Angelo, F Trinchese, O Arancio
Neurochemical research, 2003•SpringerOver the past several years researchers have engineered many transgenic models of
Alzheimer's disease. Since loss of memory is one of the major hallmarks of the disorder, the
phenotypic characterization of these animals has included both behavioral tests which aim
to evaluate learning abilities, and electrophysiological studies to analyze synaptic
transmission and long-term potentiation, a widely studied cellular model of learning and
memory. These studies are fundamental for the design of novel therapies for the treatment …
Alzheimer's disease. Since loss of memory is one of the major hallmarks of the disorder, the
phenotypic characterization of these animals has included both behavioral tests which aim
to evaluate learning abilities, and electrophysiological studies to analyze synaptic
transmission and long-term potentiation, a widely studied cellular model of learning and
memory. These studies are fundamental for the design of novel therapies for the treatment …
Abstract
Over the past several years researchers have engineered many transgenic models of Alzheimer's disease. Since loss of memory is one of the major hallmarks of the disorder, the phenotypic characterization of these animals has included both behavioral tests which aim to evaluate learning abilities, and electrophysiological studies to analyze synaptic transmission and long-term potentiation, a widely studied cellular model of learning and memory. These studies are fundamental for the design of novel therapies for the treatment and/or prevention of Alzheimer's disease.
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