Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells
MJ Kleinz, JN Skepper, AP Davenport - Regulatory peptides, 2005 - Elsevier
The novel G protein-coupled receptor APJ, recently paired with the proposed cognate
peptide ligand apelin, mediates potent vasodilator and positive inotropic actions in rats.
Radioligand binding showed apelin receptors in rat and human heart and human large
conduit vessels. The specific cell types expressing the receptor, however, have not been
determined. Apelin, the cognate receptor ligand, is present in endothelial cells. However, the
exact pathway of endothelial apelin synthesis and secretion is not known. We therefore …
peptide ligand apelin, mediates potent vasodilator and positive inotropic actions in rats.
Radioligand binding showed apelin receptors in rat and human heart and human large
conduit vessels. The specific cell types expressing the receptor, however, have not been
determined. Apelin, the cognate receptor ligand, is present in endothelial cells. However, the
exact pathway of endothelial apelin synthesis and secretion is not known. We therefore …