[HTML][HTML] Hepatic stellate cell proliferation is an early platelet-derived growth factor-mediated cellular event in rat cholestatic liver injury
N Kinnman, O Goria, D Wendum, MC Gendron… - Laboratory …, 2001 - Elsevier
After liver injury, hepatic stellate cells (HSC) undergo a pleiotropic response termed
“activation” that also occurs in culture models and ultimately leads to the conversion of HSC
into myofibroblasts expressing smooth muscle α-actin (α-SMA). The onset of HSC
proliferation in primary culture coincides with the induction of platelet-derived growth factor
receptor-β (PDGFR-β) expression, while platelet-derived growth factor (PDGF) is the most
potent mitogen for culture-activated HSC. Yet, the mechanisms and the stage of activation …
“activation” that also occurs in culture models and ultimately leads to the conversion of HSC
into myofibroblasts expressing smooth muscle α-actin (α-SMA). The onset of HSC
proliferation in primary culture coincides with the induction of platelet-derived growth factor
receptor-β (PDGFR-β) expression, while platelet-derived growth factor (PDGF) is the most
potent mitogen for culture-activated HSC. Yet, the mechanisms and the stage of activation …