Elastase-mediated release of heparan sulfate proteoglycans from pulmonary fibroblast cultures: a mechanism for basic fibroblast growth factor (bFGF) release and …
JA Buczek-Thomas, MA Nugent - Journal of Biological Chemistry, 1999 - ASBMB
We have investigated elastase-mediated alterations in the expression of basic fibroblast
growth factor (bFGF) receptors and proteoglycan co-receptors and characterized the
subsequent effects on bFGF receptor binding profiles. For these studies, pulmonary
fibroblast cultures were treated with porcine pancreatic elastase, and elastase-mediated
changes in bFGF receptor expression and binding profiles were assessed. Quantitation of
[35 S] sulfate-labeled proteoglycan and total glycosaminoglycan release from fibroblast …
growth factor (bFGF) receptors and proteoglycan co-receptors and characterized the
subsequent effects on bFGF receptor binding profiles. For these studies, pulmonary
fibroblast cultures were treated with porcine pancreatic elastase, and elastase-mediated
changes in bFGF receptor expression and binding profiles were assessed. Quantitation of
[35 S] sulfate-labeled proteoglycan and total glycosaminoglycan release from fibroblast …
