Identification of loci associated with schizophrenia by genome-wide association and follow-up
Nature genetics, 2008•nature.com
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937
controls) and tested loci with P< 10− 5 in up to 16,726 additional subjects. Of 12 loci
followed up, 3 had strong independent support (P< 5× 10− 4), and the overall pattern of
replication was unlikely to occur by chance (P= 9× 10− 8). Meta-analysis provided strongest
evidence for association around ZNF804A (P= 1.61× 10− 7) and this strengthened when the
affected phenotype included bipolar disorder (P= 9.96× 10− 9).
controls) and tested loci with P< 10− 5 in up to 16,726 additional subjects. Of 12 loci
followed up, 3 had strong independent support (P< 5× 10− 4), and the overall pattern of
replication was unlikely to occur by chance (P= 9× 10− 8). Meta-analysis provided strongest
evidence for association around ZNF804A (P= 1.61× 10− 7) and this strengthened when the
affected phenotype included bipolar disorder (P= 9.96× 10− 9).
Abstract
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10−5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 × 10−4), and the overall pattern of replication was unlikely to occur by chance (P = 9 × 10−8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 × 10−7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 × 10−9).
nature.com