BACKGROUND: Subjects with schizophrenia have decreased gray matter volume of
auditory cortex in structural imaging studies and exhibit deficits in auditory sensory
processing that might reflect impairments of feedforward and/or feedback circuits within the
auditory cortex. Recently, we reported that one component of these circuits, pyramidal cells
in deep layer 3 of the auditory association cortex (area 42), has reduced mean somal
volume in subjects with schizophrenia. To discriminate between involvement of feedforward …