Impaired mismatch negativity generation reflects widespread dysfunction of working memory in schizophrenia
DC Javitt, P Doneshka, S Grochowski… - Archives of general …, 1995 - jamanetwork.com
Background: Impaired P300 (P3) generation is one of the most robust indices of brain
dysfunction in schizophrenia. This study investigates the integrity of cognitive eventrelated
potentials that precede P3 in an" oddball" paradigm to determine the earliest stages at which
auditory information processing is impaired in schizophrenia. Methods: Cognitive event-
related potential components including mismatch negativity (MMN), N2, and P3 were
recorded from subjects with chronic schizophrenia who were receiving medication (n= 20) …
dysfunction in schizophrenia. This study investigates the integrity of cognitive eventrelated
potentials that precede P3 in an" oddball" paradigm to determine the earliest stages at which
auditory information processing is impaired in schizophrenia. Methods: Cognitive event-
related potential components including mismatch negativity (MMN), N2, and P3 were
recorded from subjects with chronic schizophrenia who were receiving medication (n= 20) …