Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics
S Akbarian, JJ Kim, SG Potkin… - Archives of general …, 1995 - jamanetwork.com
Background: Up-regulation of γ-aminobutyric acid A (GABA A) receptors and decreased
GABA uptake in the cerebral cortex of schizophrenics suggest altered GABAergic
transmission, which could be caused by primary disturbance of GABA synapses or by
decreased production of the transmitter. Decreased production could be due to a shutdown
in GABA production or to loss of GABA neurons caused by cell death or their failure to
migrate to the cortex during brain development. Methods: To discriminate between these …
GABA uptake in the cerebral cortex of schizophrenics suggest altered GABAergic
transmission, which could be caused by primary disturbance of GABA synapses or by
decreased production of the transmitter. Decreased production could be due to a shutdown
in GABA production or to loss of GABA neurons caused by cell death or their failure to
migrate to the cortex during brain development. Methods: To discriminate between these …