Can't shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals

GJ Siegle, SR Steinhauer, ME Thase, VA Stenger… - Biological …, 2002 - Elsevier
Background: Previous research suggests that depressed individuals engage in prolonged
elaborative processing of emotional information. A computational neural network model of
emotional information processing suggests this process involves sustained amygdala
activity in response to processing negative features of information. This study examined
whether brain activity in response to emotional stimuli was sustained in depressed
individuals, even following subsequent distracting stimuli. Methods: Seven depressed and …