Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus
BACKGROUND: Positron emission tomography (PET) studies of major depression have
revealed resting-state abnormalities in the prefrontal and cingulate cortices. Recently, fMRI
has been adapted to examine connectivity within a specific resting-state neural network—
the default-mode network—that includes medial prefrontal and anterior cingulate cortices.
The goal of this study was to examine resting-state, default-mode network functional
connectivity in subjects with major depression and in healthy controls. METHODS: Twenty …
revealed resting-state abnormalities in the prefrontal and cingulate cortices. Recently, fMRI
has been adapted to examine connectivity within a specific resting-state neural network—
the default-mode network—that includes medial prefrontal and anterior cingulate cortices.
The goal of this study was to examine resting-state, default-mode network functional
connectivity in subjects with major depression and in healthy controls. METHODS: Twenty …
