Expression of apoptotic and antiapoptotic markers in epithelial cells in idiopathic pulmonary fibrosis
M Plataki, AV Koutsopoulos, K Darivianaki, G Delides… - Chest, 2005 - Elsevier
Study objective Idiopathic pulmonary fibrosis (IPF) is a chronic, usually fatal lung disease of
unknown etiology. A common feature is the presence of microscopic areas of epithelial cell
dropout. Increased apoptosis of these cells could elucidate the speculative pathogenesis of
the disease. Therefore, the aim of our study was to examine the expression of p53, p21, bcl-
2, bax, and caspase-3 in association with DNA strand breaks in bronchial and alveolar
epithelial cells in lung specimens from IPF patients and control subjects. Patients and …
unknown etiology. A common feature is the presence of microscopic areas of epithelial cell
dropout. Increased apoptosis of these cells could elucidate the speculative pathogenesis of
the disease. Therefore, the aim of our study was to examine the expression of p53, p21, bcl-
2, bax, and caspase-3 in association with DNA strand breaks in bronchial and alveolar
epithelial cells in lung specimens from IPF patients and control subjects. Patients and …