Single-particle tracking: applications to membrane dynamics

MJ Saxton, K Jacobson - Annual review of biophysics and …, 1997 - annualreviews.org
MJ Saxton, K Jacobson
Annual review of biophysics and biomolecular structure, 1997annualreviews.org
▪ Abstract Measurements of trajectories of individual proteins or lipids in the plasma
membrane of cells show a variety of types of motion. Brownian motion is observed, but many
of the particles undergo non-Brownian motion, including directed motion, confined motion,
and anomalous diffusion. The variety of motion leads to significant effects on the kinetics of
reactions among membrane-bound species and requires a revision of existing views of
membrane structure and dynamics.
Abstract
Measurements of trajectories of individual proteins or lipids in the plasma membrane of cells show a variety of types of motion. Brownian motion is observed, but many of the particles undergo non-Brownian motion, including directed motion, confined motion, and anomalous diffusion. The variety of motion leads to significant effects on the kinetics of reactions among membrane-bound species and requires a revision of existing views of membrane structure and dynamics.
Annual Reviews