[HTML][HTML] The sarcolemmal calcium pump inhibits the calcineurin/nuclear factor of activated T-cell pathway via interaction with the calcineurin A catalytic subunit
MH Buch, A Pickard, A Rodriguez, S Gillies… - Journal of Biological …, 2005 - ASBMB
The calcineurin/nuclear factor of activated T-cell (NFAT) pathway represents a crucial
transducer of cellular function. There is increasing evidence placing the sarcolemmal
calcium pump, or plasma membrane calcium/calmodulin ATPase pump (PMCA), as a
potential modulator of signal transduction pathways. We demonstrate a novel interaction
between PMCA and the calcium/calmodulin-dependent phosphatase, calcineurin, in
mammalian cells. The interaction domains were located to the catalytic domain of PMCA4b …
transducer of cellular function. There is increasing evidence placing the sarcolemmal
calcium pump, or plasma membrane calcium/calmodulin ATPase pump (PMCA), as a
potential modulator of signal transduction pathways. We demonstrate a novel interaction
between PMCA and the calcium/calmodulin-dependent phosphatase, calcineurin, in
mammalian cells. The interaction domains were located to the catalytic domain of PMCA4b …
