[HTML][HTML] Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in …
GW Okunade, ML Miller, GJ Pyne, RL Sutliff… - Journal of Biological …, 2004 - ASBMB
The relative importance of plasma membrane Ca 2+-ATPase (PMCA) 1 and PMCA4 was
assessed in mice carrying null mutations in their genes (Atp2b1 and Atp2b4). Loss of both
copies of the gene encoding PMCA1 caused embryolethality, whereas heterozygous
mutants had no overt disease phenotype. Despite widespread and abundant expression of
PMCA4, PMCA4 null (Pmca4-/-) mutants exhibited no embryolethality and appeared
outwardly normal. Loss of PMCA4 impaired phasic contractions and caused apoptosis in …
assessed in mice carrying null mutations in their genes (Atp2b1 and Atp2b4). Loss of both
copies of the gene encoding PMCA1 caused embryolethality, whereas heterozygous
mutants had no overt disease phenotype. Despite widespread and abundant expression of
PMCA4, PMCA4 null (Pmca4-/-) mutants exhibited no embryolethality and appeared
outwardly normal. Loss of PMCA4 impaired phasic contractions and caused apoptosis in …
