Novel mutation in KCNA1 causes episodic ataxia with paroxysmal dyspnea
SJ Shook, H Mamsa, JC Jen… - Muscle & Nerve …, 2008 - Wiley Online Library
SJ Shook, H Mamsa, JC Jen, RW Baloh, L Zhou
Muscle & Nerve: Official Journal of the American Association of …, 2008•Wiley Online LibraryAbstract Episodic ataxia type 1 (EA1) is an autosomal‐dominant neurological disease
caused by point mutations in the potassium channel–encoding gene KCNA1. It is
characterized by attacks of ataxia and continuous myokymia. Respiratory muscle
involvement has not been previously reported in EA1. We clinically evaluated a family with
features of EA1 and paroxysmal shortness of breath. Coding and flanking intronic regions of
KCNA1 were sequenced. We identified a novel 3‐nucleotide deletion mutation in KCNA1 in …
caused by point mutations in the potassium channel–encoding gene KCNA1. It is
characterized by attacks of ataxia and continuous myokymia. Respiratory muscle
involvement has not been previously reported in EA1. We clinically evaluated a family with
features of EA1 and paroxysmal shortness of breath. Coding and flanking intronic regions of
KCNA1 were sequenced. We identified a novel 3‐nucleotide deletion mutation in KCNA1 in …
Abstract
Episodic ataxia type 1 (EA1) is an autosomal‐dominant neurological disease caused by point mutations in the potassium channel–encoding gene KCNA1. It is characterized by attacks of ataxia and continuous myokymia. Respiratory muscle involvement has not been previously reported in EA1. We clinically evaluated a family with features of EA1 and paroxysmal shortness of breath. Coding and flanking intronic regions of KCNA1 were sequenced. We identified a novel 3‐nucleotide deletion mutation in KCNA1 in the affected individuals. Our findings of a deletion mutation with unusual respiratory muscle involvement expand the genetic and clinical spectrum of EA1. Muscle Nerve, 2007
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