[HTML][HTML] Differential effects of leukocyte common antigen-related protein on biochemical and biological activities of RET-MEN2A and RET-MEN2B mutant proteins
S Qiao, T Iwashita, T Furukawa, M Yamamoto… - Journal of Biological …, 2001 - ASBMB
Protein-tyrosine-phosphatases (PTPs), in conjunction with protein-tyrosine kinases, play
essential regulatory roles in diverse cellular activities by modulating the phosphorylation
state of target proteins. Leukocyte common antigen-related (LAR) protein is a widely
expressed receptor-type protein-tyrosine-phosphatase that is implicated in the regulation of
intracellular signaling triggered by both cell adhesion and peptide growth factors. The gene
for LAR is localized to human chromosome 1p32, a region frequently deleted in tumors of …
essential regulatory roles in diverse cellular activities by modulating the phosphorylation
state of target proteins. Leukocyte common antigen-related (LAR) protein is a widely
expressed receptor-type protein-tyrosine-phosphatase that is implicated in the regulation of
intracellular signaling triggered by both cell adhesion and peptide growth factors. The gene
for LAR is localized to human chromosome 1p32, a region frequently deleted in tumors of …
