Fusion of two novel genes, RBM15 and MKL1, in the t (1; 22)(p13; q13) of acute megakaryoblastic leukemia
Z Ma, SW Morris, V Valentine, JA Herbrick, X Cui… - Nature …, 2001 - nature.com
Nature genetics, 2001•nature.com
Abstract t (1; 22) is the principal translocation of acute megakaryoblastic leukemias. Here we
show this chromosomal rearrangement to result in the fusion of two novel genes, RNA-
binding motif protein-15 (RBM15), an RNA recognition motif-encoding gene with homology
to Drosophila spen, and Megakaryoblastic Leukemia-1 (MKL1), a gene encoding an SAP
(SAF-A/B, Acinus and PIAS) DNA-binding domain.
show this chromosomal rearrangement to result in the fusion of two novel genes, RNA-
binding motif protein-15 (RBM15), an RNA recognition motif-encoding gene with homology
to Drosophila spen, and Megakaryoblastic Leukemia-1 (MKL1), a gene encoding an SAP
(SAF-A/B, Acinus and PIAS) DNA-binding domain.
Abstract
t (1; 22) is the principal translocation of acute megakaryoblastic leukemias. Here we show this chromosomal rearrangement to result in the fusion of two novel genes, RNA-binding motif protein-15 (RBM15), an RNA recognition motif-encoding gene with homology to Drosophila spen, and Megakaryoblastic Leukemia-1 (MKL1), a gene encoding an SAP (SAF-A/B, Acinus and PIAS) DNA-binding domain.
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