Multiserotype protection of mice against pneumococcal colonization of the nasopharynx and middle ear by killed nonencapsulated cells given intranasally with a …
R Malley, SC Morse, LCC Leite, APM Areas… - Infection and …, 2004 - Am Soc Microbiol
Infection and immunity, 2004•Am Soc Microbiol
Intranasal challenge of C57BL/6 mice with Streptococcus pneumoniae serotypes 6B, 14,
and 23F produced colonization of the middle ear and NP. Intranasal vaccination with
ethanol-killed nonencapsulated cells with adjuvant protected both sites. Of four nontoxic
adjuvants tested, the cholera toxin B subunit was most effective and least nonspecifically
protective.
and 23F produced colonization of the middle ear and NP. Intranasal vaccination with
ethanol-killed nonencapsulated cells with adjuvant protected both sites. Of four nontoxic
adjuvants tested, the cholera toxin B subunit was most effective and least nonspecifically
protective.
Abstract
Intranasal challenge of C57BL/6 mice with Streptococcus pneumoniae serotypes 6B, 14, and 23F produced colonization of the middle ear and NP. Intranasal vaccination with ethanol-killed nonencapsulated cells with adjuvant protected both sites. Of four nontoxic adjuvants tested, the cholera toxin B subunit was most effective and least nonspecifically protective.
American Society for Microbiology