[HTML][HTML] Solution structure of the factor H-binding protein, a survival factor and protective antigen of Neisseria meningitidis
F Cantini, D Veggi, S Dragonetti, S Savino… - Journal of biological …, 2009 - ASBMB
Factor H-binding protein is a 27-kDa lipoprotein of Neisseria meningitidis discovered while
screening the bacterial genome for vaccine candidates. In addition to being an important
component of a vaccine against meningococcus in late stage of development, the protein is
essential for pathogenesis because it allows the bacterium to survive and grow in human
blood by binding the human complement factor H. We recently reported the solution
structure of the C-terminal domain of factor H-binding protein, which contains the …
screening the bacterial genome for vaccine candidates. In addition to being an important
component of a vaccine against meningococcus in late stage of development, the protein is
essential for pathogenesis because it allows the bacterium to survive and grow in human
blood by binding the human complement factor H. We recently reported the solution
structure of the C-terminal domain of factor H-binding protein, which contains the …