Streptococcus pneumoniae Pilus Subunits Protect Mice against Lethal Challenge
C Gianfaldoni, S Censini, M Hilleringmann… - Infection and …, 2007 - Am Soc Microbiol
C Gianfaldoni, S Censini, M Hilleringmann, M Moschioni, C Facciotti, W Pansegrau…
Infection and immunity, 2007•Am Soc MicrobiolStreptococcus pneumoniae is a major public health threat worldwide. The recent discovery
that this pathogen possesses pili led us to investigate their protective abilities in a mouse
model of intraperitoneal infection. Both active and passive immunization with recombinant
pilus subunits afforded protection against lethal challenge with the S. pneumoniae serotype
4 strain TIGR4.
that this pathogen possesses pili led us to investigate their protective abilities in a mouse
model of intraperitoneal infection. Both active and passive immunization with recombinant
pilus subunits afforded protection against lethal challenge with the S. pneumoniae serotype
4 strain TIGR4.
Abstract
Streptococcus pneumoniae is a major public health threat worldwide. The recent discovery that this pathogen possesses pili led us to investigate their protective abilities in a mouse model of intraperitoneal infection. Both active and passive immunization with recombinant pilus subunits afforded protection against lethal challenge with the S. pneumoniae serotype 4 strain TIGR4.
American Society for Microbiology