The conditioning prior to allogeneic stem cell transplantation was originally designed as a
myeloablative conditioning, designed to eliminate malignant or genetically abnormal cells
and then use the transplant procedure for rescue of the patients or to replace missing bone
marrow products. However, allografts can induce effective graft vs. malignancy effects and
can also eliminate undesirable hematopoietic stem cells in patients with genetic disorders
and autoimmune diseases, thus documenting that alloreactive effects mediated by donor …