Evidence for the role of reactive nitrogen species in polymicrobial sepsis-induced renal peritubular capillary dysfunction and tubular injury
L Wu, N Gokden, PR Mayeux - Journal of the American Society of …, 2007 - journals.lww.com
Acute kidney injury (AKI) remains a frequent and serious complication of human sepsis that
contributes significantly to mortality. For better understanding of the development of AKI
during sepsis, the cecal ligation and puncture (CLP) murine model of sepsis was studied
using intravital video microscopy (IVVM) of the kidney. IVVM with FITC-dextran was used to
determine the percentage of capillaries with continuous, intermittent or no flow at 0 (sham),
10, 16, and 22 h after CLP. There was a dramatic fall in capillary perfusion as early as 10 h …
contributes significantly to mortality. For better understanding of the development of AKI
during sepsis, the cecal ligation and puncture (CLP) murine model of sepsis was studied
using intravital video microscopy (IVVM) of the kidney. IVVM with FITC-dextran was used to
determine the percentage of capillaries with continuous, intermittent or no flow at 0 (sham),
10, 16, and 22 h after CLP. There was a dramatic fall in capillary perfusion as early as 10 h …
