Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study
JA Kellum, L Kong, MP Fink, LA Weissfeld… - Archives of internal …, 2007 - jamanetwork.com
Background Severe sepsis is common and frequently fatal, and community-acquired
pneumonia (CAP) is the leading cause. Although severe sepsis is often attributed to
uncontrolled and unbalanced inflammation, evidence from humans with infection syndromes
across the breadth of disease is lacking. In this study we describe the systemic cytokine
response to pneumonia and determine if specific patterns, including the balance of
proinflammatory and anti-inflammatory markers, are associated with severe sepsis and …
pneumonia (CAP) is the leading cause. Although severe sepsis is often attributed to
uncontrolled and unbalanced inflammation, evidence from humans with infection syndromes
across the breadth of disease is lacking. In this study we describe the systemic cytokine
response to pneumonia and determine if specific patterns, including the balance of
proinflammatory and anti-inflammatory markers, are associated with severe sepsis and …
