Preclinical trial of L-arginine monotherapy alone or with N-acetylcysteine in septic shock
AC Kalil, JE Sevransky, DE Myers, C Esposito… - Critical care …, 2006 - journals.lww.com
Objective: l-arginine supplementation in sepsis is controversial. Septic shock has been
alternatively viewed as an l-arginine-deficient state or as a syndrome caused by excess
nitric oxide, an end-product of l-arginine metabolism. Design: Randomized, placebo-
controlled, and double-blinded (investigators, veterinarians, and pharmacists). Setting:
Laboratory. Subjects: Purpose-bred, 1-to 2-yr-old, 10-to 12-kg beagles. Interventions: The
effects of parenteral l-arginine alone or in combination with N-acetylcysteine were compared …
alternatively viewed as an l-arginine-deficient state or as a syndrome caused by excess
nitric oxide, an end-product of l-arginine metabolism. Design: Randomized, placebo-
controlled, and double-blinded (investigators, veterinarians, and pharmacists). Setting:
Laboratory. Subjects: Purpose-bred, 1-to 2-yr-old, 10-to 12-kg beagles. Interventions: The
effects of parenteral l-arginine alone or in combination with N-acetylcysteine were compared …
