Epiregulin, a novel epidermal growth factor (EGF)-related growth regulating peptide, was
purified from conditioned medium of the mouse fibroblast-derived tumor cell line
NIH3T3/clone T7. It was a 46-amino-acid single chain polypeptide, and its amino acid
sequence exhibited 24-50% amino acid sequence identity with sequences of other EGF-
related growth factors. Epiregulin exhibited bifunctional regulatory properties: it inhibited the
growth of several epithelial tumor cells and stimulated the growth of fibroblasts and various …