Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized
Y Ruan, L Tecott, MM Jiang… - Proceedings of the …, 2001 - National Acad Sciences
Y Ruan, L Tecott, MM Jiang, LY Jan, YN Jan
Proceedings of the National Academy of Sciences, 2001•National Acad SciencesNeurogenic genes in the Notch receptor-mediated signaling pathway play important roles in
neuronal cell fate specification as well as neuronal differentiation. The Drosophila
neuralized gene is one of the neurogenic genes. We have cloned a mouse homolog of
Drosophila neuralized, m-neu1, and found that the m-neu1 transcript is expressed in
differentiated neurons. Mice deficient for m-neu1 are viable and morphologically normal, but
exhibit specific defects in olfactory discrimination and hypersensitivity to ethanol. These …
neuronal cell fate specification as well as neuronal differentiation. The Drosophila
neuralized gene is one of the neurogenic genes. We have cloned a mouse homolog of
Drosophila neuralized, m-neu1, and found that the m-neu1 transcript is expressed in
differentiated neurons. Mice deficient for m-neu1 are viable and morphologically normal, but
exhibit specific defects in olfactory discrimination and hypersensitivity to ethanol. These …
Neurogenic genes in the Notch receptor-mediated signaling pathway play important roles in neuronal cell fate specification as well as neuronal differentiation. The Drosophila neuralized gene is one of the neurogenic genes. We have cloned a mouse homolog of Drosophila neuralized, m-neu1, and found that the m-neu1 transcript is expressed in differentiated neurons. Mice deficient for m-neu1 are viable and morphologically normal, but exhibit specific defects in olfactory discrimination and hypersensitivity to ethanol. These findings reveal an essential role of m-neu1 in ensuring proper processing of certain information in the adult brain.
National Acad Sciences