Five cases of a syndrome previously reported as Cowden's disease are reported. The
disorder is composed of a complex mixture of ectodermal, mesodermal, and endodermal
hamartomatous lesions of which mucocutaneous, breast, thyroid, and gastrointestinal
tumors are most often encountered. The mucocutaneous lesions are thought to represent
the most distinctive elements of this syndrome and consist of lichenoid and papillomatous
lesions of the face and ears, acrokeratotic lesions of the hands, papillomatous and papular …