Accumulation of MFG-E8/lactadherin on exosomes from immature dendritic cells
P Véron, E Segura, G Sugano, S Amigorena… - Blood Cells, Molecules …, 2005 - Elsevier
Exosomes are vesicles of endocytic origin secreted spontaneously by dendritic cells (DCs).
We have shown previously that exosomes can transfer antigen or MHC–peptide complexes
between DCs, thus potentially amplifying the immune response. We had also identified milk
fat globule EGF/factor VIII (MFG-E8), also called lactadherin, as one of the major exosomal
proteins. MFG-E8 has two domains: an Arg–Gly–Asp sequence that binds integrins αvβ3
and αvβ5 (expressed by human DCs and macrophages) and a phosphatidyl–serine (PS) …
We have shown previously that exosomes can transfer antigen or MHC–peptide complexes
between DCs, thus potentially amplifying the immune response. We had also identified milk
fat globule EGF/factor VIII (MFG-E8), also called lactadherin, as one of the major exosomal
proteins. MFG-E8 has two domains: an Arg–Gly–Asp sequence that binds integrins αvβ3
and αvβ5 (expressed by human DCs and macrophages) and a phosphatidyl–serine (PS) …
