p63–Key molecule in the early phase of epithelial abnormality in idiopathic pulmonary fibrosis
K Murata, S Ota, T Niki, A Goto, CP Li… - … and molecular pathology, 2007 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is the most common lung disease predisposing lung
cancer. To clarify the early phase of epithelial abnormalities in IPF, we used an in vitro
squamous metaplasia model, transforming growth factor β1 (TGF β1)-treated airway
epithelial cells (BEAS-2B). The model repeated the expression of squamous epithelial
character, such as involucrin, and keratin 6 and 14. DNA microarray analysis disclosed a
unique expression signature in TGF β1-treated airway epithelial cells, 20 specifically up …
cancer. To clarify the early phase of epithelial abnormalities in IPF, we used an in vitro
squamous metaplasia model, transforming growth factor β1 (TGF β1)-treated airway
epithelial cells (BEAS-2B). The model repeated the expression of squamous epithelial
character, such as involucrin, and keratin 6 and 14. DNA microarray analysis disclosed a
unique expression signature in TGF β1-treated airway epithelial cells, 20 specifically up …