Focal adhesion kinase is overexpressed in hepatocellular carcinoma and can be served as an independent prognostic factor
T Fujii, K Koshikawa, S Nomoto, O Okochi, T Kaneko… - Journal of …, 2004 - Elsevier
BACKGROUND/AIMS: The development of human malignancies can be attributed to
aberrant regulation of intracellular signal transduction pathways. In the current study, we
aimed to evaluate focal adhesion kinase (FAK), a non-receptor tyrosine kinase, expression
in hepatocellular carcinoma (HCC), and to explore the prognostic significance of FAK.
METHODS: We investigated FAK mRNA expression in 60 HCC specimens using
quantitative real-time reverse transcription polymerase chain reaction analysis, and the …
aberrant regulation of intracellular signal transduction pathways. In the current study, we
aimed to evaluate focal adhesion kinase (FAK), a non-receptor tyrosine kinase, expression
in hepatocellular carcinoma (HCC), and to explore the prognostic significance of FAK.
METHODS: We investigated FAK mRNA expression in 60 HCC specimens using
quantitative real-time reverse transcription polymerase chain reaction analysis, and the …