[HTML][HTML] Increased reactive oxygen species production down-regulates peroxisome proliferator-activated α pathway in C2C12 skeletal muscle cells
A Cabrero, M Alegret, RM Sánchez, T Adzet… - Journal of Biological …, 2002 - ASBMB
Generation of reactive oxygen species may contribute to the pathogenesis of diseases
involving intracellular lipid accumulation. To explore the mechanisms leading to these
pathologies we tested the effects of etomoxir, an inhibitor of carnitine palmitoyltransferase I
which contains a fatty acid-derived structure, in C2C12 skeletal muscle cells. Etomoxir
treatment for 24 h resulted in a down-regulation of peroxisome proliferator-activated receptor
α (PPARα) mRNA expression, achieving an 87% reduction at 80 μm etomoxir. The mRNA …
involving intracellular lipid accumulation. To explore the mechanisms leading to these
pathologies we tested the effects of etomoxir, an inhibitor of carnitine palmitoyltransferase I
which contains a fatty acid-derived structure, in C2C12 skeletal muscle cells. Etomoxir
treatment for 24 h resulted in a down-regulation of peroxisome proliferator-activated receptor
α (PPARα) mRNA expression, achieving an 87% reduction at 80 μm etomoxir. The mRNA …