[HTML][HTML] Clinical significance of p53 alterations in surgically treated prostate cancers
T Schlomm, L Iwers, P Kirstein, B Jessen, J Köllermann… - Modern pathology, 2008 - Elsevier
Despite the high number of previous studies, the role of p53 alterations in prostate cancer is
not clearly defined. To address the role of p53 alterations in prostate cancer biology, a total
of 2514 cancers treated by radical prostatectomy were successfully analyzed by
immunohistochemistry in a tissue microarray format. Overall a low rate of p53-positive
tumors was found (2.5%). A significant underestimation of p53-positive cases was excluded
by subsequent large section analyses and direct sequencing of the p53 gene in subsets of …
not clearly defined. To address the role of p53 alterations in prostate cancer biology, a total
of 2514 cancers treated by radical prostatectomy were successfully analyzed by
immunohistochemistry in a tissue microarray format. Overall a low rate of p53-positive
tumors was found (2.5%). A significant underestimation of p53-positive cases was excluded
by subsequent large section analyses and direct sequencing of the p53 gene in subsets of …
