RETRACTED: Rac-1 and IQGAP are potential regulators of E-cadherin–catenin interactions during murine preimplantation development
Adherens junction formation is fundamental for compaction and trophectoderm
differentiation during mammalian preimplantation development. We recently isolated an
IQGAP-2 cDNA from a differential display-polymerase chain reaction screen of bovine
preimplantation developmental stages. IQGAP-1 and-2 proteins mediate E-cadherin-based
cell-to-cell adhesion through interactions with b-catenin and the Rho GTPases, rac1 and
cdc42. Our study demonstrates IQGAP-1,-2, rac-1 and cdc42 mRNAs are present throughout …
differentiation during mammalian preimplantation development. We recently isolated an
IQGAP-2 cDNA from a differential display-polymerase chain reaction screen of bovine
preimplantation developmental stages. IQGAP-1 and-2 proteins mediate E-cadherin-based
cell-to-cell adhesion through interactions with b-catenin and the Rho GTPases, rac1 and
cdc42. Our study demonstrates IQGAP-1,-2, rac-1 and cdc42 mRNAs are present throughout …
Abstract
Adherens junction formation is fundamental for compaction and trophectoderm differentiation during mammalian preimplantation development. We recently isolated an IQGAP-2 cDNA from a differential display-polymerase chain reaction screen of bovine preimplantation developmental stages. IQGAP-1 and-2 proteins mediate E-cadherin-based cell-to-cell adhesion through interactions with b-catenin and the Rho GTPases, rac1 and cdc42. Our study demonstrates IQGAP-1,-2, rac-1 and cdc42 mRNAs are present throughout murine preimplantation development. IQGAP-1 and rac-1 protein distribution changes from predominantly plasma membrane associated to predominantly cytoplasmic as the embryo progresses through cleavage divisions and compaction to the blastocyst stage. q 2002 Elsevier Science BV All rights reserved.
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