The mechanisms by which synchronized embryonic development to the blastocyst stage,
preparation of the uterus for the receptive state, and reciprocal embryo-uterine interactions
for implantation are coordinated are still unclear. We show in this study that preimplantation
embryo development became asynchronous in mice that are deficient in brain-type (CB1)
and/or spleen-type (CB2) cannabinoid receptor genes. Furthermore, whereas the levels of
uterine anandamide (endocannabinoid) and blastocyst CB1 are coordinately down …