[HTML][HTML] Dexamethasone-induced gene 2 (dig2) is a novel pro-survival stress gene induced rapidly by diverse apoptotic signals
Z Wang, MH Malone, MJ Thomenius, F Zhong… - Journal of Biological …, 2003 - ASBMB
Glucocorticoid hormones induce apoptosis in lymphoid cells. This process requires de novo
RNA/protein synthesis. Here we report the identification and cloning of a novel
dexamethasone-induced gene designated dig2. Using Affymetrix oligonucleotide microarray
analysis of∼ 10,000 genes and expressed sequence tags, we found that the expression of
dig2 mRNA is significantly induced not only in the murine T cell lymphoma lines S49. A2 and
WEHI7. 2 but also in normal mouse thymocytes following dexamethasone treatment. This …
RNA/protein synthesis. Here we report the identification and cloning of a novel
dexamethasone-induced gene designated dig2. Using Affymetrix oligonucleotide microarray
analysis of∼ 10,000 genes and expressed sequence tags, we found that the expression of
dig2 mRNA is significantly induced not only in the murine T cell lymphoma lines S49. A2 and
WEHI7. 2 but also in normal mouse thymocytes following dexamethasone treatment. This …