Duchenne muscular dystrophy (DMD) is a fatal childhood disease caused by mutations that
abolish the expression of dystrophin in muscle. Utrophin is a paralogue of dystrophin and
can functionally replace it in skeletal muscle. A method to induce utrophin up-regulation in
muscle should therefore be therapeutically useful in DMD. We have previously shown that
there are two full-length utrophin mRNA species: A and B. Here we describe the generation
and characterization of antibodies specific to A-and B-utrophin. We show that both mRNA …