Protective effects of 16, 16-dimethyl PGE2 on the liver and kidney
MJ Ruwart, BD Rush, NM Friedle, RC Piper, GJ Kolaja - Prostaglandins, 1981 - Elsevier
Abstract The ability of subcutaneous 16, 16-dimethyl PGE 2 to protect the liver and the
kidney against damage induced by carbon tetrachloride and ANIT (alpha-
napthylisothiocyanate) was examined. Rats were given 5–75 μg/kg of 16, 16-dimethyl PGE
2 24 and 0.5 hrs before challenge with 1 ml of oral carbon tetrachloride with an additional
prostaglandin dose 6 hrs later. Twenty-four hrs after carbon tetrachloride animals were
sacrificed by decapitation. 16, 16-Dimethyl PGE 2 partially prevented fat accumulation and …
kidney against damage induced by carbon tetrachloride and ANIT (alpha-
napthylisothiocyanate) was examined. Rats were given 5–75 μg/kg of 16, 16-dimethyl PGE
2 24 and 0.5 hrs before challenge with 1 ml of oral carbon tetrachloride with an additional
prostaglandin dose 6 hrs later. Twenty-four hrs after carbon tetrachloride animals were
sacrificed by decapitation. 16, 16-Dimethyl PGE 2 partially prevented fat accumulation and …
