[HTML][HTML] Prostaglandin E2 protects gastric mucosal cells from apoptosis via EP2 and EP4 receptor activation
T Hoshino, S Tsutsumi, W Tomisato, HJ Hwang… - Journal of Biological …, 2003 - ASBMB
Prostaglandin E 2 (PGE 2) has a strong protective effect on the gastric mucosain vivo;
however, the molecular mechanism of a direct cytoprotective effect of PGE 2 on gastric
mucosal cells has yet to be elucidated. Although we reported previously that PGE 2 inhibited
gastric irritant-induced apoptotic DNA fragmentation in primary cultures of guinea pig gastric
mucosal cells, we show here that PGE 2 inhibits the ethanol-dependent release of
cytochrome c from mitochondria. Of the four main subtypes of PGE 2 receptors, we also …
however, the molecular mechanism of a direct cytoprotective effect of PGE 2 on gastric
mucosal cells has yet to be elucidated. Although we reported previously that PGE 2 inhibited
gastric irritant-induced apoptotic DNA fragmentation in primary cultures of guinea pig gastric
mucosal cells, we show here that PGE 2 inhibits the ethanol-dependent release of
cytochrome c from mitochondria. Of the four main subtypes of PGE 2 receptors, we also …