Phospholipase A2 enzymes
I Kudo, M Murakami - Prostaglandins & other lipid mediators, 2002 - Elsevier
Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane
glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including
prostaglandins and leukotrienes. The same reaction also produces lysophosholipids, which
represent another class of lipid mediators. So far, at least 19 enzymes that possess PLA2
activity have been identified and cloned in mammals. The secretory PLA2 (sPLA2) family, in
which 10 isozymes have been identified, consists of low-molecular weight, Ca2+-requiring …
glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including
prostaglandins and leukotrienes. The same reaction also produces lysophosholipids, which
represent another class of lipid mediators. So far, at least 19 enzymes that possess PLA2
activity have been identified and cloned in mammals. The secretory PLA2 (sPLA2) family, in
which 10 isozymes have been identified, consists of low-molecular weight, Ca2+-requiring …