Pathways and functions of the Werner syndrome protein
JW Lee, J Harrigan, PL Opresko, VA Bohr - Mechanisms of ageing and …, 2005 - Elsevier
Mutations in human WRN (also known as RECQ3) gene give rise to a rare autosomal
recessive genetic disorder, Werner syndrome (WS). WS is a premature aging disease
characterized by predisposition to cancer and early onset of symptoms related to normal
aging including osteoporosis, ocular cataracts, graying and loss of hair, diabetes mellitus,
arteriosclerosis, and atherosclerosis. This review focuses on the functional role of Werner
protein (WRN) in guarding the genetic stability of cells, particularly by playing an integral …
recessive genetic disorder, Werner syndrome (WS). WS is a premature aging disease
characterized by predisposition to cancer and early onset of symptoms related to normal
aging including osteoporosis, ocular cataracts, graying and loss of hair, diabetes mellitus,
arteriosclerosis, and atherosclerosis. This review focuses on the functional role of Werner
protein (WRN) in guarding the genetic stability of cells, particularly by playing an integral …